A small peptide inhibits siRNA amplification in plants by mediating autophagic degradation of SGS3/RDR6-bodies

ABSTRACT: Selective autophagy mediates specific degradation of unwanted cytoplasmic components to maintain cellular homeostasis. The Suppressor of Gene Silencing 3 (SGS3) and RNA-dependent RNA polymerase 6 (RDR6)-formed bodies (SGS3/RDR6-bodies) are essential for siRNA amplification in planta. However, whether autophagy receptors regulate selective turnover of SGS3/RDR6-bodies is unknown. By analyzing the transcriptomic response to virus infection in Arabidopsis, we identified a virus-induced small peptide 1 (VISP1) composed of 71 amino acids, which harbor a ubiquitin-interacting motif that mediates interaction with autophagy-related protein 8. Overexpression of VISP1 induced selective autophagy and compromised antiviral immunity by inhibiting SGS3/RDR6-dependent viral siRNA amplification, whereas v

SUBMITTER: Dr. Xin Tong 

PROVIDER: S-SCDT-EMBOJ-2021-108050P | biostudies-other |

REPOSITORIES: biostudies-other