Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues

ABSTRACT: Brown and beige fat are specialized for energy expenditure by dissipating energy from glucose and fatty acid oxidation as heat. While glucose and fatty acid metabolism has been extensively studied in thermogenic adipose tissues, the involvement of amino acids in regulating adaptive thermogenesis remains little studied. Here, we report that asparagine supplementation in brown and beige adipocytes drastically upregulated the thermogenic transcriptional program and lipogenic gene expression, so that asparagine-fed mice showed better cold tolerance. In mice with diet-induced obesity, the asparagine-fed group was more responsive to β3-adrenergic receptor agonists, manifesting in blunted body weight gain and improved glucose tolerance. Metabolomics and 13C-glucose flux analysis revealed that asp

SUBMITTER: Yingjiang Xu 

PROVIDER: S-SCDT-EMBOJ-2021-108069 | biostudies-other |

REPOSITORIES: biostudies-other