Balancing the length of the distal tip by Septins is key for stability and signalling function of primary cilia

ABSTRACT: Primary cilia are antenna-like organelles required for signalling transduction. How cilia structure is mechanistically maintained at steady-state to promote signalling is largely unknown. Here, we define that mammalian primary cilia axonemes are formed by proximal and distal segments delineated by tubulin polyglutamylation-rich and -poor regions, respectively. The analysis of proximal/distal segmentation indicated that perturbations leading to cilia over-elongation influenced proximal or distal segment length with a different impact on cilia behaviour. We identified Septins as novel repressors of distal segment growth. We show that Septins control the localisation of MKS3 and CEP290 required for a functional transition zone, and the cilia tip accumulation of the microtubule-capping kinesin

SUBMITTER: Dr. Taishi Kanamaru 

PROVIDER: S-SCDT-EMBOJ-2021-108843 | biostudies-other |

REPOSITORIES: biostudies-other