MiR-124-dependent tagging of synapses by synaptopodin enables input-specific homeostatic plasticity

ABSTRACT: Homeostatic synaptic plasticity is a process by which neurons adjust their synaptic strength to compensate for perturbations in neuronal activity. Whether the highly diverse synapses on a neuron respond uniformly to the same perturbation remains unclear. Moreover, the molecular determinants that underlie synapse-specific homeostatic synaptic plasticity are unknown. Here, we report a synaptic tagging mechanism in which the ability of individual synapses to increase their strength in response to activity-deprivation depends on the local expression of the spine-apparatus protein synaptopodin under the regulation of miR-124. By using genetic manipulations to alter synaptopodin expression or regulation by miR-124, we show that synaptopodin behaves as a "postsynaptic tag" whose translation is de

SUBMITTER: Dr. Sandra Dubes 

PROVIDER: S-SCDT-EMBOJ-2021-109012 | biostudies-other |

REPOSITORIES: biostudies-other