Ageing induces tissue specific transcriptomic changes in Caenorhabditis elegans

ABSTRACT: Ageing is a complex process with common and distinct features across tissues. Unveiling the underlying processes driving ageing in individual tissues is indispensable to decipher the mechanisms of organismal longevity. C. elegans is a well-established model organism that has spearheaded ageing research with the discovery of numerous genetic pathways controlling its lifespan. However, it remains challenging to dissect the ageing of worm tissues due to the limited description of tissue pathology and access to tissue-specific molecular changes during ageing. In this study, we isolated cells from five major tissues in young and old worms and profiled the age-induced transcriptomic changes within these tissues. We observed a striking diversity of ageing across tissues and identified different s

SUBMITTER: Dr. Yidong Shen 

PROVIDER: S-SCDT-EMBOJ-2021-109633 | biostudies-other |

REPOSITORIES: biostudies-other