Mouse circulating extracellular vesicles contain virus-derived siRNAs active in antiviral immunity

ABSTRACT: Induction and suppression of antiviral RNA interference (RNAi) has been observed in mammals during infection with at least seven distinct RNA viruses, including some that are pathogenic in humans. However, while the cell-autonomous immune response mediated by antiviral RNAi is gradually being recognized, little is known about systemic antiviral RNAi in mammals. Furthermore, extracellular vesicles (EVs) also function in viral signal spreading and host immunity. Here, we show that upon antiviral RNAi activation, virus-derived small-interfering RNAs (vsiRNAs) from Nodamura virus (NoV), Sindbis virus (SINV), and Zika virus (ZIKV) enter the murine bloodstream via EVs for systemic circulation. vsiRNAs in the EVs are biologically active, since they confer RNA- RNA homology-dependent antiviral act

SUBMITTER: Prof. yang li 

PROVIDER: S-SCDT-EMBOJ-2021-109902 | biostudies-other |

REPOSITORIES: biostudies-other