Rewiring Phospholipid Biosynthesis Reveals Resilience to Membrane Perturbations

ABSTRACT: The organelles of eukaryotic cells differ in their membrane lipid composition. This heterogeneity is achieved by the localization of lipid synthesizing and modifying enzymes to specific compartments, as well as by intracellular lipid transport that utilizes vesicular and non-vesicular routes to ferry lipids from their place of synthesis to their destination. For instance, the major and essential phospholipids, phosphatidylethanolamine (PE) and phosphatidylcholine (PC) can be produced by multiple pathways and, in the case of PE, also at multiple locations. However, the molecular components that underlie lipid homeostasis as well as the routes allowing their distribution remain unclear. Here, we present an approach in which we simplify and rewire yeast phospholipid synthesis by redirecting P

SUBMITTER: Dr. Arun, T. John Peter 

PROVIDER: S-SCDT-EMBOJ-2021-109998 | biostudies-other |

REPOSITORIES: biostudies-other