Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining mRNAs

ABSTRACT: The nuclear envelope has long been considered primarily a physical barrier separating nuclear and cytosolic contents. More recently, nuclear compartmentalization has been shown to have additional regulatory functions in controlling gene expression. A sizeable proportion of protein-coding mRNAs is more prevalent in the nucleus than in the cytosol, suggesting regulated mRNA trafficking to the cytosol, but the mechanisms underlying controlled nuclear mRNA retention remain unclear. Here, we provide a comprehensive map of the subcellular localization of mRNAs in mature mouse cortical neurons, and reveal that transcripts retained in the nucleus comprise the majority of stable intron-retaining mRNAs. Systematically probing the fate of nuclear transcripts upon neuronal stimulation, we found opposi

SUBMITTER: Maxime Mazille 

PROVIDER: S-SCDT-EMBOJ-2021-110192 | biostudies-other |

REPOSITORIES: biostudies-other