Astrogenesis in the murine dentate gyrus is a life-long and dynamic process

ABSTRACT: Astrocytes are highly abundant in the mammalian brain and their functions are of vital importance for all aspects of development, adaption and aging of the central nervous system (CNS). Mounting evidence indicates the important contributions of astrocytes to a wide range of neuropathies. Still our understanding of astrocyte development significantly lags behind that of other CNS cells. We here combine immunohistochemical approaches with genetic fate-mapping, behavioural paradigms, single cell transcriptomics and in vivo two-photon imaging, to comprehensively assess the generation and proliferation of astrocytes in the dentate gyrus (DG) across the lifespan of a mouse. Astrogenesis in the DG is initiated by radial glia-like neural stem cells giving rise to locally dividing astrocytes that e

SUBMITTER: Ms. Julia Schneider 

PROVIDER: S-SCDT-EMBOJ-2021-110409 | biostudies-other |

REPOSITORIES: biostudies-other