Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells

ABSTRACT: Maintenance of stemness is tightly linked to cell cycle regulation through protein phosphorylation by cyclin-dependent kinases (CDKs). However, how this process is reversed during differentiation is unknown. We report here that exit from stemness and differentiation of pluripotent cells along the neural lineage is controlled by CDC14, a CDK-counteracting phosphatase whose function in mammals remains obscure. Lack of the two CDC14 family members, CDC14A and CDC14B results in deficient development of the neural system in the mouse, and impairs neural differentiation from embryonic stem cells (ESCs). Mechanistically, CDC14 directly dephosphorylates specific proline-directed Ser/Thr residues of Undifferentiated embryonic Transcription Factor 1 (UTF1) during the exit from stemness, triggering i

SUBMITTER: Dr. Carolina Villarroya-Beltri 

PROVIDER: S-SCDT-EMBOJ-2022-111251 | biostudies-other |

REPOSITORIES: biostudies-other