YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis

ABSTRACT: Dysfunction of the homeostasis-maintaining systems in specific cell types or tissues renders the organism susceptible to a range of diseases, including cancers. One of the emerging mechanisms for maintaining tissue homeostasis is cellular senescence. Here we report that the Hippo pathway plays a critical role in controlling the fate of ovarian cells. Hyperactivation of Yes-Associated Protein 1 (YAP1), the major effector of the Hippo pathway, induces senescence in cultured primary human ovarian surface epithelial cells (hOSEs). Large tumor suppressor 2 (LATS2), the primary upstream negative regulator of YAP1, is elevated in both YAP1-induced and natural replicative-triggered senescence. Deletion of LATS2 in hOSEs prevents these cells from natural replicative and YAP1-induced senescence. Mos

SUBMITTER: Chunbo He 

PROVIDER: S-SCDT-EMBOR-2017-44948V1 | biostudies-other |

REPOSITORIES: biostudies-other