Functional interplay between c-Myc and Max in B lymphocyte differentiation

ABSTRACT: The Myc family of oncogenic transcription factors regulates myriad cellular functions. Myc proteins contain a basic region/helix-loop-helix/leucine zipper domain that mediates DNA binding and heterodimerization with its partner Max. Among the Myc proteins, c-Myc is the most widely expressed, and relevant in primary B lymphocytes. There is evidence suggesting that c-Myc can perform some of its functions in the absence of Max in different cellular contexts. However, the functional in vivo interplay between c-Myc and Max during B lymphocyte differentiation is not well understood. Using in vivo and ex vivo models, we show that while c-Myc requires Max in primary B lymphocytes, several key biological processes, like cell differentiation and DNA replication, can initially progress without the fo

SUBMITTER: Ms. Mercedes Pérez-Olivares 

PROVIDER: S-SCDT-EMBOR-2018-45770-T | biostudies-other |

REPOSITORIES: biostudies-other