UBTD1 is a mechano-regulator controlling cancer aggressiveness

ABSTRACT: Ubiquitin domain-containing protein 1 (UBTD1) is highly evolutionary conserved and has been described to interact with E2 enzymes of the ubiquitin proteasome system. However, its biological role and the functional significance of this interaction remain largely unknown. Here, we demonstrate that depletion of UBTD1 drastically affects the mechanical properties of epithelial cancer cells via RhoA activation, and strongly promotes their aggressiveness. On a stiff matrix, UBTD1 expression is regulated by cell-cell contacts, and the protein is associated with ?-catenin at cell junctions. Yes associated protein (YAP), is a major cell mechano-transducer, and we show that UBTD1 is associated with components of the YAP degradation complex. Interestingly, UBTD1 promotes the interaction of YAP with i

SUBMITTER: Dr. Stéphanie Torrino 

PROVIDER: S-SCDT-EMBOR-2018-46570V1 | biostudies-other |

REPOSITORIES: biostudies-other