H2B monoubiquitination is a key epigenetic regulator of ferroptosis and is regulated by p53

ABSTRACT: H2B monoubiquitination (H2Bub1) is a key epigenetic modification that plays significant roles in multiple biological processes, although the global functions of H2Bub1 are still poorly understood. Ferroptosis is a newly identified form of non-apoptotic cell death whose regulatory mechanisms remain unclear. However, whether nuclear events participate in the regulation of ferroptosis is undetermined. Here, our study demonstrated that H2Bub1 levels are decreased during erastin treatment, and loss of H2Bub1 increases the cellular sensitivity to erastin-induced ferroptosis through epigenetically regulating the expression of SLC7A11, a key regulator of ferroptosis. Furthermore, we show that the tumor suppressor p53 negatively regulates H2Bub1 levels independently of p53's transcription factor ac

SUBMITTER: Dr. Su Chen 

PROVIDER: S-SCDT-EMBOR-2018-47563V1 | biostudies-other |

REPOSITORIES: biostudies-other