Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/?-catenin modulator Annexin A1

ABSTRACT: Fusobacterium nucleatum, a Gram-negative oral anaerobe, is a significant contributor to colorectal cancer. Using an in vitro cancer progression model, we discover that F. nucleatum stimulates the growth of colorectal cancer cells without affecting the pre-cancerous adenoma cells. Annexin A1, a previously unrecognized modulator of Wnt/?-catenin signaling, is a key component through which F. nucleatum exerts its stimulatory effect. It is specifically expressed in proliferating colorectal cancer cells and involved in activation of cyclin D1. Annexin A1 expression level in colon cancer is a predictor of poor prognosis independent of cancer stage, grade, age and sex. The FadA adhesin from F. nucleatum up-regulates Annexin A1 expression through E-cadherin. A positive feedback loop between FadA a

SUBMITTER: Prof. Yiping Han 

PROVIDER: S-SCDT-EMBOR-2018-47638V1 | biostudies-other |

REPOSITORIES: biostudies-other