Interleukin-12/23 deficiency differentially affects pathology in male and female Alzheimer's disease-like mice

ABSTRACT: Pathological aggregation of amyloid-? (A?) is a main hallmark of Alzheimer's disease (AD). Recent genetic association studies have linked innate immune system actions to AD development and current evidence suggests profound gender differences in AD pathogenesis. Here, we characterise gender-specific pathologies in the APP23 AD-like mouse model and find that female mice show stronger amyloidosis and astrogliosis compared with male mice. We tested the gender-specific effect of lack of IL12p40, the shared subunit of interleukin (IL)-12 and IL-23, that we previously reported to ameliorate pathology in APPPS1 mice. IL12p40 deficiency gender-specifically reduces A? plaque burden in male APP23 mice, while in female mice a significant reduction of soluble A?1-40 without changes in A? plaque burden

SUBMITTER: Pascale Eede 

PROVIDER: S-SCDT-EMBOR-2019-48530V1 | biostudies-other |

REPOSITORIES: biostudies-other