TLR4-dependent shaping of the wound site by MSCs accelerates wound healing

ABSTRACT: We here address the question whether the unique capacity of mesenchymal stem cells to re-establish tissue homeostasis depends on their potential to sense pathogen associated molecular pattern and, in consequence, mount an adaptive response in the interest of tissue repair. After injection of MSCs primed with the bacterial wall component LPS into murine wounds an unexpected acceleration of healing occurs, clearly exceeding that of non-primed MSCs. This correlates with a fundamental reprogramming of the transcriptome in LPS treated MSCs as deduced from RNAseq analysis and its validation. A network of genes mediating the adaptive response through the toll like receptor 4 (TLR4) pathway responsible for neutrophil and macrophage recruitment and their activation profoundly contributes to enhanc

SUBMITTER: Prof. Karin Scharffetter-Kochanek 

PROVIDER: S-SCDT-EMBOR-2019-48777V1 | biostudies-other |

REPOSITORIES: biostudies-other