Mitochondrial protein biogenesis in the synapse is supported by local translation

ABSTRACT: Synapses are the regions of the neuron that enable the transmission and propagation of action potentials on the cost of high energy consumption and elevated demand for mitochondrial ATP production. The rapid changes in local energetic requirements at dendritic spines imply the role of mitochondria in the maintenance of their homeostasis. Using global proteomic analysis supported with complementary experimental approaches, we show that an essential pool of mitochondrial proteins is locally produced at the synapse indicating that mitochondrial protein biogenesis takes place locally to maintain functional mitochondria in axons and dendrites. Furthermore, we show that stimulation of synaptoneurosomes induces the local synthesis of mitochondrial proteins that are transported to the mitochondria

SUBMITTER: Dr. Bozena Kuzniewska 

PROVIDER: S-SCDT-EMBOR-2019-48882V1 | biostudies-other |

REPOSITORIES: biostudies-other