IGF1R regulates retrograde axonal transport of signalling endosomes in motor neurons

ABSTRACT: Signalling endosomes are essential for trafficking of activated ligand-receptor complexes and their distal signalling, ultimately leading to neuronal survival. Although deficits in signalling endosome transport have been linked to neurodegeneration, our understanding of the mechanisms controlling this process remains incomplete. Here we describe a new modulator of signalling endosome trafficking, the insulin-like growth factor 1 receptor (IGF1R). We show that IGF1R inhibition increases the velocity of signalling endosomes in motor neuron axons, both in vitro and in vivo. This effect is specific, since IGF1R inhibition does not alter the axonal transport of mitochondria or lysosomes. Our results suggest that this change in trafficking is linked to the dynein adaptor bicaudal D1 (BICD1), as

SUBMITTER: Prof. Giampietro Schiavo 

PROVIDER: S-SCDT-EMBOR-2019-49129-T | biostudies-other |

REPOSITORIES: biostudies-other