Streptococcus pneumoniae highjacks host autophagy by deploying CbpC as a decoy for Atg14 depletion

ABSTRACT: Pneumococcal cell surface-exposed choline-binding proteins (CBPs) play pivotal roles in multiple infectious processes with pneumococci. Intracellular pneumococci can be recognized at multiple steps during bactericidal autophagy. However, whether CBPs are involved in pneumococci-induced autophagic processes remains unknown. In this study, we demonstrate that CbpC from S. pneumoniae strain TIGR4 activates autophagy through an interaction with Atg14. However, S. pneumoniae also interferes with autophagy by deploying CbpC as a decoy to cause autophagic degradation of Atg14 through an interaction with p62/SQSTM1. Thus, S. pneumoniae suppresses the autophagic degradation of intracellular pneumococci and survives within cells. Domain analysis reveals that the coiled-coil domain of Atg14 and resid

SUBMITTER: Ms. Sayaka Shizukuishi 

PROVIDER: S-SCDT-EMBOR-2019-49232V1 | biostudies-other |

REPOSITORIES: biostudies-other