Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity

ABSTRACT: Changes in composition of the intestinal microbiota are linked to the development of obesity and can lead to endothelial cell (EC) dysfunction. It is unknown whether EC can directly influence the microbiota. Insulin like growth factor-1 (IGF-1) and its receptor (IGF-1R), are critical for coupling nutritional status and cellular growth; IGF-1R is expressed in multiple cell types including EC. The role of ECIGF-1R in the response to nutritional obesity is unexplored. To examine this, we use gene-modified mice with EC specific over-expression of human IGF-1R (hIGFREO) and their wildtype littermates. After high-fat feeding, hIGFREO weigh less, have reduced adiposity and have improved glucose tolerance. hIGFREO show an altered gene expression and altered microbial diversity in the gut, includin

SUBMITTER: Dr. Natalie, Jayne Haywood 

PROVIDER: S-SCDT-EMBOR-2020-50767V1 | biostudies-other |

REPOSITORIES: biostudies-other