Asymmetry in the frequency and position of mitosis in the mouse embryo epiblast at gastrulation

ABSTRACT: At gastrulation, a subpopulation of epiblast cells constitutes a transient posteriorly located structure called the primitive streak, where cells that undergo epithelial-mesenchymal transition make up the mesoderm and endoderm lineages. Mouse embryo epiblast cells were labeled ubiquitously or in a mosaic fashion. Cell shape, packing, organization and division were recorded through live imaging during primitive streak formation. Posterior epiblast displays a higher frequency of rosettes, some of which associated with a central cell undergoing mitosis. Cells at the primitive streak, in particular delaminating cells, undergo mitosis more frequently than other epiblast cells. In pseudostratified epithelia, mitosis takes place at the apical side of the epithelium. However, mitosis is not rest

SUBMITTER: Navrita Mathiah 

PROVIDER: S-SCDT-EMBOR-2020-50944V1 | biostudies-other |

REPOSITORIES: biostudies-other