Melanopsin elevates locomotor activity during the wake state of the diurnal zebrafish

ABSTRACT: Mammalian and fish pineals play a key role in adapting behaviour to the ambient light conditions through the release of melatonin. In mice, light inhibits nocturnal locomotor activity via the non-visual photoreceptor Melanopsin. In contrast to the extensively studied function of Melanopsin in the indirect regulation of the rodent pineal, its role in the intrinsically photosensitive zebrafish pineal has not been elucidated. Therefore, it is not evident if the light signalling mechanism is conserved between distant vertebrates, and how Melanopsin could affect diurnal behaviour. A double knockout of opn4.1 and opn4xb was generated in the diurnal zebrafish, which manifests attenuated locomotor activity during the wake state. Transcriptome sequencing gave insight into pathways downstream of Mel

SUBMITTER: Dr. Marcus, P.S. Dekens 

PROVIDER: S-SCDT-EMBOR-2020-51528V1 | biostudies-other |

REPOSITORIES: biostudies-other