Pervasive compartment-specific regulation of gene expression during homeostatic synaptic scaling

ABSTRACT: Synaptic scaling is a form of homeostatic plasticity which allows neurons to adjust their action potential firing rate in response to chronic alterations in neural activity. Synaptic scaling requires profound changes in gene expression, but the relative contribution of local and cell-wide mechanisms is controversial. Here we perform a comprehensive multi-omics characterization of the somatic and process compartments of primary rat hippocampal neurons during synaptic scaling. We uncover both highly compartment-specific and correlating changes in the neuronal transcriptome and proteome. Whereas downregulation of crucial regulators of neuronal excitability occurs primarily in the somatic compartment, structural components of excitatory postsynapses are mostly downregulated in processes. Local

SUBMITTER: David Colameo 

PROVIDER: S-SCDT-EMBOR-2020-52094V1 | biostudies-other |

REPOSITORIES: biostudies-other