MicroRNA-181a restricts human γδ T cell differentiation by targeting Map3k2 and Notch2

ABSTRACT: γδ T cells are a conserved population of lymphocytes that contribute to anti-tumor responses through overt type 1 inflammatory and cytotoxic properties. We have previously shown that human γδ T cells acquire this profile upon stimulation with IL-2 or IL-15, in a differentiation process dependent on MAPK/ERK signaling. Here, we identify microRNA-181a as a key modulator of human γδ T cell functional differentiation. We observe that miR-181a is highly expressed in patients with prostate cancer, and that this pattern associates with lower expression of NKG2D, a critical mediator of cancer surveillance. Interestingly, miR-181a expression negatively correlates with an activated type 1 effector profile obtained from in vitro differentiated γδ T cells; and miR-181a overexpression restricts their l

SUBMITTER: Ms. Gisela Gordino 

PROVIDER: S-SCDT-EMBOR-2020-52234V1 | biostudies-other |

REPOSITORIES: biostudies-other