Nhp2 is a reader of H2AQ105me and part of a network integrating metabolism with rRNA synthesis

ABSTRACT: Ribosome biogenesis is an essential cellular process that requires integration of extracellular cues, such as metabolic state, with intracellular signaling, transcriptional regulation and chromatin accessibility at the ribosomal DNA. Here, we demonstrate that the recently identified histone modification, methylation of H2AQ105 (H2AQ105me), is an integral part of a dynamic chromatin network at the rDNA locus. Its deposition depends on a functional mTor signaling pathway as well as acetylation of histone H3 at position K56, thus integrating metabolic and proliferative signals.. Furthermore, we identify a first epigenetic reader of this modification, the ribonucleoprotein Nhp2, which specifically recognizes H2AQ105me. Based on functional and proteomic data we suggest that Nhp2 functions as an

SUBMITTER: Julia, S.P. Mawer 

PROVIDER: S-SCDT-EMBOR-2021-52435V1 | biostudies-other |

REPOSITORIES: biostudies-other