Placenta Derived Interferon Stimulated Gene 20 Controls ZIKA Virus Infection

ABSTRACT: Zika virus is a positive-sense single-stranded RNA virus, which can be transmitted across the placenta and has adverse effects on fetal development during pregnancy. The severity of these complications highlights the importance of prevention and treatment. However, no vaccines or drugs are currently available. In this study, we characterize the IFN?-mediated antiviral response in trophoblast cells in order to identify critical components that are necessary for the successful control of viral replication and determine whether components of the IFN-induced response can be used as a replacement therapy for ZIKA virus infection during pregnancy. We identify and characterize interferon stimulated gene 20 (ISG20) as playing a central role in controlling Zika virus infection in trophoblast cells,

SUBMITTER: Dr. Jiahui Ding 

PROVIDER: S-SCDT-EMBOR-2021-52450V1 | biostudies-other |

REPOSITORIES: biostudies-other