Dual control of dopamine in Drosophila myeloid-like progenitor cell proliferation and regulation of lymph gland growth

ABSTRACT: In Drosophila, definitive hematopoiesis takes place in "lymph gland". It harbours progenitor cells whose development controls its growth and formation of mature blood cells. With respect to its development, neurotransmitters have emerged as regulators of blood-progenitor development and function. In this study, we investigate neurotransmitter dopamine and show that progenitors are self-sufficient with regards to synthesising it. These cells have modules for dopamine sensing through the receptor, transporter. We found that modulating expression of these components in progenitor cells affected lymph gland growth, which suggested its growth-promoting function. Cell-cycle analysis of developing lymph glands revealed a requirement for intracellular-dopamine in moderating the progression of earl

SUBMITTER: Dr. Tina Mukherjee 

PROVIDER: S-SCDT-EMBOR-2021-52951V1 | biostudies-other |

REPOSITORIES: biostudies-other