Gut neuroendocrine signaling regulates synaptic assembly in C. elegans

ABSTRACT: Synaptic connections are essential to build a functional brain. How synapses are formed during development is a fundamental question in neuroscience. Recent studies provided evidence that the gut plays an important role in neuronal development through processing signals derived from gut microbes or nutrients. Defects in gut-brain communication can lead to various neurological disorders. Although the roles of the gut in communicating signals from its internal environment to the brain are well known, it remains unclear whether the gut plays a genetically encoded role in neuronal development. Using C. elegans as a model, we uncover that a Wnt-endocrine signaling pathway in the gut regulates synaptic development in the brain. A canonical Wnt signaling pathway promotes synapse formation through

SUBMITTER: Ms. Yanjun Shi 

PROVIDER: S-SCDT-EMBOR-2021-53267V1 | biostudies-other |

REPOSITORIES: biostudies-other