MYDGF protects bone mass by inhibiting osteoclastogenesis and promoting osteoblast differentiation

ABSTRACT: Whether bone marrow regulates bone metabolism through endocrine and paracrine mechanism remains largely unknown. Here we found that 1) myeloid cell specific myeloid-derived growth factor (MYDGF) deficiency decreased bone mass and bone strength in young and aged mice. 2) myeloid cell specific MYDGF restoration prevented decreases in bone mass and bone strength in MYDGF knockout mice, moreover, myeloid cell derived MYDGF improved the progress of bone defects healing, prevented ovariectomy (OVX)-induced bone loss and age-related osteoporosis. 3) MYDGF inhibited osteoclastogenesis and promoted osteoblast differentiation in vivo and in vitro. 4) PKCβ-NF-B and MAPK1/3-STAT3 pathways were involved in the regulation of MYDGF on bone metabolism. Thus, we concluded that myeloid cell derived MYDGF i

SUBMITTER: Xiaoli Xu 

PROVIDER: S-SCDT-EMBOR-2021-53509V1 | biostudies-other |

REPOSITORIES: biostudies-other