Developmental cell death of cortical projection neurons is controlled by a Bcl11a/Bcl6-dependent pathway

ABSTRACT: Developmental neuron death plays a pivotal role in refining organization and wiring during neocortex formation. Aberrant regulation of this process results in neurodevelopmental disorders including impaired learning and memory. Underlying molecular pathways are incompletely determined. Loss of Bcl11a in cortical projection neurons induces pronounced cell death in upper-layer cortical projection neurons during postnatal corticogenesis. We use this genetic model to explore genetic mechanisms by which developmental neuron death is controlled. Unexpectedly, we find Bcl6, previously shown to be involved in transition of cortical neurons from progenitor to postmitotic differentiation state to provide a major check point regulating neuron survival during late cortical development. We show that Bc

SUBMITTER: Christoph Wiegreffe 

PROVIDER: S-SCDT-EMBOR-2021-54104V1 | biostudies-other |

REPOSITORIES: biostudies-other