Endothelial-immune crosstalk contributes to vasculopathy in non-alcoholic fatty liver disease

ABSTRACT: The top cause of mortality in patients with non-alcoholic fatty liver disease (NAFLD) is cardiovascular complications. However, mechanisms of NAFLD-associated vasculopathy remain understudied. Here, we show that blood outgrowth endothelial cells (BOECs) from NAFLD subjects exhibit global transcriptional upregulation of chemokines and human leukocyte antigens. In mouse models of diet-induced NAFLD, we confirm heightened endothelial expressions of CXCL12 in the aortas and the liver vasculatures, as well as increased retention of infiltrated leukocytes within the vessel walls. To elucidate endothelial-immune crosstalk, we performed immunoprofiling by single-cell analysis, uncovering T cell intensification in NAFLD patients. Functionally, treatment with a CXCL12 neutralizing antibody is effect

SUBMITTER: Dr. Chun-Yi Ng 

PROVIDER: S-SCDT-EMBOR-2021-54271V1P | biostudies-other |

REPOSITORIES: biostudies-other