A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation

ABSTRACT: The primary cilium constitutes an organelle that orchestrates signal transduction independently from the cell body. Dysregulation of this intricate molecular architecture leads to severe human diseases, commonly referred to as ciliopathies. However, the molecular underpinnings how ciliary signaling orchestrates a specific cellular output remain elusive. By combining spatially-resolved optogenetics with RNA sequencing and imaging, we reveal a novel cAMP signalosome that is functionally distinct from the cytoplasm. We identify the genes and pathways targeted by the ciliary cAMP signalosome and shed light on the underlying mechanisms and downstream signaling. We reveal that chronic stimulation of the ciliary cAMP signalosome transforms kidney epithelia from tubules into cysts. Counteracting t

SUBMITTER: Dr. Jan, Niklas Hansen 

PROVIDER: S-SCDT-EMBOR-2021-54315-T | biostudies-other |

REPOSITORIES: biostudies-other