Ca2+-independent transmission at the central synapse formed between dorsal root ganglion and dorsal horn neurons

ABSTRACT: A central principle of synaptic transmission is that action potential-induced presynaptic neurotransmitter release occurs exclusively via Ca2+-dependent secretion (CDS). The discovery and mechanistic investigations of Ca2+-independent but voltage-dependent secretion (CiVDS) have demonstrated that the action potential per se is sufficient to trigger neurotransmission in the somata of primary sensory and sympathetic neurons in mammals. One key question remains, however, whether CiVDS contributes to central synaptic transmission. Here we report, in the central transmission from presynaptic (dorsal root ganglion) to postsynaptic (spinal dorsal horn) neurons in vitro, (1) excitatory postsynaptic currents (EPSCs) are mediated by glutamate transmission through both CiVDS (up to 87%) and CDS; (2)

SUBMITTER: Dr. Yuan Wang 

PROVIDER: S-SCDT-EMBOR-2021-54507V1 | biostudies-other |

REPOSITORIES: biostudies-other