Efficacy of systemically delivered temozolomide-activated phage-targeted gene therapy in human glioblastoma.

ABSTRACT: Glioblastoma multiforme (GBM) is the most lethal primary intracranial malignant neoplasm in adults and most resistant to treatment. Integration of gene therapy and chemotherapy, chemovirotherapy, has the potential to improve treatment. We have introduced an intravenous bacteriophage (phage) vector for dual targeting of therapeutic genes to glioblastoma. It is a hybrid AAV/phage, AAVP, designed to deliver a recombinant adeno-associated virus genome (rAAV) by the capsid of M13 phage. In this vector, dual tumor targeting is first achieved by phage capsid display of the RGD4C ligand that binds the ?v?3 integrin receptor. Second, genes are expressed from a tumor-activated and temozolomide (TMZ)-induced promoter of the glucose-regulated protein, Grp78. Here we investigated systemic combination t

SUBMITTER: Ms. Justyna, Magdalena Przystal 

PROVIDER: S-SCDT-EMM-2017-08492 | biostudies-other |

REPOSITORIES: biostudies-other