Endothelial Notch signaling controls insulin transport in muscle

ABSTRACT: The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of a repertoire of angiocrine molecules, regulate metabolic demands in an organ-specific manner. Insulin flux across the endothelium to muscle cells is a rate-limiting process influencing insulin-mediated lowering of blood glucose. Here we demonstrate that Notch signaling in ECs regulates insulin transport to muscle. Notch signaling activity was higher in ECs isolated from obese mice compared to non-obese. Sustained Notch signaling in ECs lowered insulin sensitivity and increased blood glucose levels. On the contrary, EC-specific inhibition of Notch signaling increased insulin sensitivity, improved glucose tolerance and glucose uptake i

SUBMITTER: Dr. Sana, Safatul Hasan 

PROVIDER: S-SCDT-EMM-2018-09271 | biostudies-other |

REPOSITORIES: biostudies-other