Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration

ABSTRACT: While adult mammalian skeletal muscle is stable due to its post-mitotic nature, muscle regeneration is still essential throughout life for maintaining functional fitness. During certain diseases, such as the modern pandemics of obesity and diabetes, the regeneration process becomes impaired, leading to the loss of muscle function and contributes to the global burden of these diseases. However, the underlying mechanisms of the impairment are not well defined. Here we identify mGPDH as a critical regulator of skeletal muscle regeneration. Specifically, it regulates myogenic markers and myoblast differentiation by controlling mitochondrial biogenesis via CaMKKβ/AMPK. mGPDH-/- attenuated skeletal muscle regeneration in vitro and in vivo while mGPDH overexpression ameliorated dystrophic patholo

SUBMITTER: Dr. Xiufei Liu 

PROVIDER: S-SCDT-EMM-2018-09390 | biostudies-other |

REPOSITORIES: biostudies-other