Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

ABSTRACT: Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression have remained incompletely understood. We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis, is activated in an AD mouse model and human AD. Therefore, using a conditional knockout approach, we deleted Stat3 specifically in astrocytes in the APP/PS1 model of AD. We find that Stat3-deficient APP/PS1 mice show decreased ?-amyloid levels and plaque burden. Plaque-close microglia displayed a more complex morphology, internalized more ?-amyloid and upregulated amyloid clearance pathways in Stat3-deficient mice. Moreover, astrocyte-specific Stat3-deficient APP/PS1 mice showed decreased pro-inflam

SUBMITTER: Dr. Nicole Reichenbach 

PROVIDER: S-SCDT-EMM-2018-09665 | biostudies-other |

REPOSITORIES: biostudies-other