Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

ABSTRACT: Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of variants in genes selectively expressed in microglia are associated with an increased risk for neurodegenerative diseases such as Alzheimer's disease (AD) and Frontotemporal lobar degeneration (FTLD). Among these genes are progranulin (GRN) and the triggering receptor expressed on myeloid cells 2 (TREM2). Both cause neurodegeneration by mechanisms involving loss-of-function. We have now isolated microglia from Grn-/- mice and compared their transcriptomes to those of Trem2-/- mice. Surprisingly, while loss of Trem2 enhances the expression of genes associated with a homeostatic state, microglia derived from Grn-/- mice showed a

SUBMITTER: Julia, K Götzl 

PROVIDER: S-SCDT-EMM-2018-09711 | biostudies-other |

REPOSITORIES: biostudies-other