Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with obesity and may progress to non-alcoholic steatohepatitis (NASH) and liver fibrosis. The deficit of pharmacological therapies for the latter mainly results from an incomplete understanding of involved pathological mechanisms. Herein, we identify apoptosis signal-regulating kinase 1 (ASK1) as a suppressor of NASH and fibrosis formation. High fat diet-fed and aged chow-fed liver-specific ASK1-knockout mice develop a higher degree of hepatic steatosis, inflammation and fibrosis compared to controls. In addition, pharmacological inhibition of ASK1 increased hepatic lipid accumulation in wild-type mice. In line, liver-specific ASK1 overexpression protected mice from the development of high fat diet-induced hepatic steatosis a

SUBMITTER: Tenagne, D Challa 

PROVIDER: S-SCDT-EMM-2018-10124 | biostudies-other |

REPOSITORIES: biostudies-other