A circRNA signature predicts postoperative recurrence in stage II/III colon cancer

ABSTRACT: Accurate risk stratification for patients with stage II/III colon cancer is pivotal for postoperative treatment decisions. Here, we aimed to identify and validate a circRNA-based signature that could improve postoperative prognostic stratification for these patients. In current retrospective analysis, we included 667 patients with R0 resected stage II/III colon cancer. Using RNA-seq analysis of 20 paired frozen tissues collected post-operation, we profiled differential circRNA expression between patients with and without recurrence, followed by quantitative validation. With clinical information, we generated a four-circRNA-based cirScore to classify patients into high-risk and low-risk groups in the training cohort. The patients with high cirScores in the training cohort had a shorter dise

SUBMITTER: Prof. Rui-hua Xu 

PROVIDER: S-SCDT-EMM-2018-10168 | biostudies-other |

REPOSITORIES: biostudies-other