Genetically engineered distal airway stem cells transplantation protects mice from pulmonary infection

ABSTRACT: Severe pulmonary infection is a major threat to human health accompanied by substantial medical costs, prolonged inpatient requirements, and high mortality rates. New anti-microbial therapeutic strategies are urgently required to address the emergence of antibiotic resistance and persistent bacterial infections. In this study, we show that constitutive expression of a native anti-microbial peptide LL37 in transgenic mice aids in clearing Pseudomonas aeruginosa (PAO1), a major pathogen of clinical pulmonary infection. Orthotopic transplantation of adult mouse distal airway stem cells (DASCs), genetically engineered to express LL-37, into injured mouse lung foci enabled large scale incorporation of cells and long-term release of the host defense peptide, protecting the mice from bacterial pn

SUBMITTER: Yueqing Zhou 

PROVIDER: S-SCDT-EMM-2018-10233 | biostudies-other |

REPOSITORIES: biostudies-other