3,4-Dimethoxychalcone induces autophagy through activation of transcription factors TFE3 and TFEB

ABSTRACT: Caloric restriction mimetics (CRMs) are natural or synthetic compounds that mimic the health-promoting and longevity-extending effects of caloric restriction. CRMs provoke the deacetylation of cellular proteins coupled to an increase in autophagic flux in the absence of toxicity. Here we report the identification of a novel candidate CRM, namely, 3,4-dimethoxychalcone (3,4-DC), among a library of polyphenols. When added to several different human cell lines, 3,4-DC induced the deacetylation of cytoplasmic proteins and stimulated autophagic flux. At difference with other well-characterized CRMs, 3,4-DC, however, required transcription factor EB (TFEB) and E3 (TFE3)-dependent gene transcription and mRNA translation to trigger autophagy. 3,4-DC stimulated the translocation of TFEB and TFE3 in

SUBMITTER: Guo Chen 

PROVIDER: S-SCDT-EMM-2019-10469 | biostudies-other |

REPOSITORIES: biostudies-other