RIPK1-mediated immunogenic cell death promotes anti-tumour immunity against soft-tissue sarcoma

ABSTRACT: Drugs that mobilize the immune system against cancer are dramatically improving care for many people. Dying ca¬¬ncer cells play an active role in inducing anti-tumour immunity but not every form of death can elicit an immune response. Moreover, resistance to apoptosis is a major problem in cancer treatment and disease control. While the term 'immunogenic cell death' is not fully defined, activation of Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) can induce a type of death that mobilises the immune system against cancer. However, no clinical treatment protocols have yet been established that would harness the immunogenic potential of RIPK1. Here, we report the first pre-clinical application of an in vivo treatment protocol for soft-tissue sarcoma that directly engages RIPK

SUBMITTER: Prof. Pascal Meier 

PROVIDER: S-SCDT-EMM-2019-10979 | biostudies-other |

REPOSITORIES: biostudies-other