ANGPTL4 exacerbates pancreatitis by augmenting acinar cell injury through upregulation of C5a.

ABSTRACT: Pancreatitis is the inflammation of the pancreas. However, little is known about the genes associated with pancreatitis severity. Our microarray analysis of pancreatic tissues from mild and severe acute pancreatitis mice models identified angiopoietin-like 4 (ANGPTL4) as one of the most significantly up-regulated genes. Clinically, ANGPTL4 expression was also increased in the serum and pancreatic tissues of pancreatitis patients. The deficiency in ANGPTL4 in mice, either by gene deletion or neutralizing antibody, mitigated pancreatitis-associated pathological outcomes. Conversely, exogenous ANGPTL4 exacerbated pancreatic injury with elevated cytokine levels and apoptotic cell death. High ANGPTL4 enhanced macrophage activation and infiltration into the pancreas, which increased complement c

SUBMITTER: Mrs. Kyung Hee Jung 

PROVIDER: S-SCDT-EMM-2019-11222 | biostudies-other |

REPOSITORIES: biostudies-other