BAM15 Mediated Mitochondrial Uncoupling Protects Against Obesity and Improves Glycemic Control

ABSTRACT: Obesity is a leading cause of preventable death worldwide. Despite this, current strategies for the treatment of obesity remain ineffective at achieving long-term weight control. This is due, in part, to difficulties in identifying tolerable and efficacious small molecules or biologics capable of regulating systemic nutrient homeostasis. Here we demonstrate that BAM15, a mitochondrially targeted small molecule protonophore, stimulates energy expenditure and glucose and lipid metabolism to protect against diet-induced obesity. Exposure to BAM15 in vitro enhanced mitochondrial respiratory kinetics, improved insulin action, and stimulated nutrient uptake by sustained activation of AMPK. C57BL/6J mice treated with BAM15 were resistant to weight gain. Furthermore, BAM15 treated mice exhibited i

SUBMITTER: Christopher, L Axelrod 

PROVIDER: S-SCDT-EMM-2020-12088 | biostudies-other |

REPOSITORIES: biostudies-other