Higher CSF sTREM2 and microglia activation associate with slower rate of beta-amyloid accumulation

ABSTRACT: Microglia activation is the brain's major immune response to amyloid plaques in Alzheimer's disease (AD). Both cerebrospinal fluid (CSF) levels of soluble TREM2 (sTREM2), a biomarker of microglia activation, and microglia-PET are increased in AD; however, whether an increase in these biomarkers is associated with reduced amyloid-beta (A?) accumulation remains unclear. To address this question, we pursued a two-pronged translational approach. Firstly, in non-demented and demented individuals, we tested CSF sTREM2 at baseline to predict 1) amyloid-PET changes over 2 years and 2) tau PET cross-sectionally assessed in a subset of patients. We found higher CSF sTREM2 associated with attenuated amyloid-PET increase and lower tau-PET. Secondly, in the AppNL-G-F mouse model of amyloidosis, we stud

SUBMITTER: Prof. Michael Ewers 

PROVIDER: S-SCDT-EMM-2020-12308 | biostudies-other |

REPOSITORIES: biostudies-other