CXCR4 engagement triggers CD47 internalization and antitumor immunization in a mouse model of mesothelioma

ABSTRACT: Boosting antitumor immunity has emerged as a powerful strategy in cancer treatment. While releasing T cell brakes has received most attention, tumor recognition by T cells is a pre-requisite. Radiotherapy and certain cytotoxic drugs induce the release of Damage Associated Molecular Patterns, which promote tumor antigen cross-presentation and T cell priming. Antibodies against the "do not eat me" signal CD47 cause macrophage phagocytosis of live tumor cells and drive the emergence of antitumor T cells. Here we show that CXCR4 activation, so far associated only with tumor progression and metastasis, also flags tumor cells to immune recognition. Both CXCL12, the natural CXCR4 ligand, and BoxA, a fragment of HMGB1, promote the release of DAMPs and the internalization of CD47, leading to protec

SUBMITTER: Rosanna Mezzapelle 

PROVIDER: S-SCDT-EMM-2020-12344 | biostudies-other |

REPOSITORIES: biostudies-other