SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function

ABSTRACT: Glycine transporters regulate levels of brain glycine, a coagonist for NMDA receptors, and are important therapeutic targets of disorders with suppressed NMDAR function. However, it remains unclear whether other transporters in the brain can also regulate glycine levels and NMDAR function. We report that SLC6A20A, an imino acid transporter of proline, regulates proline/glycine levels and NMDAR function in the mouse brain. SLC6A20 transcript and protein levels were increased in mutant mice with PTEN lacking the C-terminus through enhanced B-catenin binding to the Slc6a20a gene.These mice displayed reduction of proline and glycine and decreased NMDAR currents. Elevating glycine levels back to normal ranges by antisense-oligonucleotide-induced SLC6A20 knockdown, or the competitive GlyT1 anta

SUBMITTER: Dr. Mihyun Bae 

PROVIDER: S-SCDT-EMM-2020-12632 | biostudies-other |

REPOSITORIES: biostudies-other