Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics

ABSTRACT: Long-range communication between tumor cells and the lymphatic vasculature defines competency for metastasis in different cancer types, particularly in melanoma. Nevertheless, the discovery of selective blockers of lymphovascular niches has been compromised by the paucity of experimental systems for whole-body analyses of tumor progression. Here we exploit immunocompetent and immunodeficient mouse models for live imaging of Vegfr3-driven neolymphangiogenesis, as a versatile platform for drug screening in vivo. Spatio-temporal analyses of autochthonous melanomas and patient-derived xenografts identified double-stranded RNA mimics (dsRNA nanoplexes) as potent inhibitors of neolymphangiogenesis, metastasis and post-surgical disease relapse. Mechanistically, dsRNA nanoplexes were found to exer

SUBMITTER: Dr. David Olmeda 

PROVIDER: S-SCDT-EMM-2020-12924 | biostudies-other |

REPOSITORIES: biostudies-other